康普博奥(杭州)生物科技有限公司
地址:浙江省杭州市萧山区知恒巷18号凯风科技3号楼10层
电话:13162084687
www.completeomics.com
来自创始团队的临床大队列多组学
学术成果展示(部分)
对200多例胰腺癌及对照组
织进行了蛋白、糖基化等
全面的蛋白基因组学分析,
揭示了驱动PDAC表型的
分子特征,为PDAC早期
检测和识别新的治疗靶点
铺平道路。
对来自11项研究泛癌队列,
包括1110名未接受治疗患
者的样本,揭示标志性癌
症进展过程中与蛋白质乙
酰化和磷酸化变化的泛癌
模式,揭示了潜在的治疗
途径。
对10种癌症类型的1000
多例泛肿瘤多组学分析,
产生整合蛋白质基因组
谱数据,加速对癌症基
本分子机制的理解。
对108例未治疗原发性肺
鳞状细胞癌及癌旁组织进
行蛋白基因组学分析,发
现多个精准治疗新靶点。
文章首次涵盖磷酸化、乙
酰化和泛素化等多翻译后
修饰组。
文献名 发表杂志 IF 发表年份
Cancer-Associated Mutations in Endometriosis without Cancer NEJM 176.082 2017
A proteogenomic portrait of lung squamous cell carcinoma Cell 64.5 2021
Integrated proteogenomic characterization across major histological
types of pediatric brain cancer Cell 64.5 2020
Integrated proteogenomic characterization of clear cell renal cell
carcinoma Cell 64.5 2020
Pan-cancer analysis of post-translational modifications reveals shared
patterns of protein regulation Cell 64.5 2023
Pan-cancer proteogenomics connects oncogenic drivers to functional
states
Cell 64.5 2023
Proteogenomic analysis of human colon cancer reveals new therapeutic
opportunities Cell 64.5 2019
Proteogenomic characterization of endometrial carcinoma Cell 64.5 2020
Proteogenomic characterization of pancreatic ductal adenocarcinoma Cell 64.5 2021
Proteogenomic characterization reveals therapeutic vulnerabilities in lung
adenocarcinoma Cell 64.5 2020
Proteogenomic landscape of breast cancer tumorigenesis and targeted
therapy Cell 64.5 2020
A draft map of the human proteome Nature 64.8 2014
Proteogenomic characterization of human colon and rectal cancer Nature 64.8 2014
Proteogenomics connects somatic mutations to signalling in breast
cancer
Nature 64.8 2016